主要科研领域与方向
　　运用细胞及分子免疫学方法研究免疫细胞发育与功能的调节及其在免疫相关疾病发病中的作用机理。

　　主要研究内容
　　树突状细胞亚群发育与功能关系的研究
　　造血干细胞向免疫细胞定向分化的调节
　　树突状细胞在诱导免疫耐受中的作用

　Selected Publications
　·Proietto AI, van Dommelen S, Zhou P, Rizzitelli A, D'Amico A, Steptoe RJ, Naik SH, Lahoud MH, Liu Y, Zheng P, Shortman K and Wu L. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci. USA. 2008; 105:19869-19874.
　·Naik SH, Sathe P, Park HY, Metcalf D, Proietto AI, Dakic A, Carotta S, O'Keeffe M, Bahlo M, Papenfuss A, Kwak JY, Wu L, Shortman K. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol. 2007; 8:1217-26
　·Wu L, Liu YJ. Development of dendritic-cell lineages. Immunity. 2007 26:741-50.
　·Naik SH, Metcalf D, van Nieuwenhuijze A, Wicks I, Wu L, O'Keeffe M, Shortman K. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol. 2006; 7:663-71.
　·Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature. 2006; 439:84-88.
　·Metcalf D, Dakic A, Mifsud S, Di Rago L, Wu L, Nutt S. Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia. Proc Natl Acad Sci USA. 2006; 103:1486-91.
　·Dakic A, Metcalf D, Di Rago L, Mifsud S, Wu L*, Nutt SL* (equal last author). PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med. 2005; 20:1487-502.
　·Nutt SL, Metcalf D, D'Amico A, Polli M, Wu L. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med. 2005; 201:221-231.
　·Dakic A, Shao QX, D’Amico A, O’Keeffe M, Chen WF, Shortman K, and Wu L. Development of the Dendritic Cell System during Mouse Ontogeny. J. Immunol. 2004; 172: 1018–1027.
　·D’Amico A and Wu L. The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid pre-Dendritic Cells are within the Bone Marrow Hemopoietic Precursors Expressing Flt3. J. Exp. Med. 2003;198:293-303.
　·Wu L, D'Amico A, Hochrein H, O’Keeffe M, Shortman K and Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001; 98:3376-3382.
　·Mori S, Shortman K, Wu L. Characterisation of thymus seeding precursor cells from mouse bone marrow. Blood 2001; 98: 696-704.
　·Vremec D, Pooley J, Hochrein H, Wu L, and Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen.  J.Immunol. 2000;164:2978-2986.
　·Wu L, D’Amico A, Winkel K.D, Suter M, Lo D, Shortman K. RelB is essential for the development of Myeloid-related CD8- dendritic cells but not of lymphoid-related CD8+ dendritic cells.  Immunity 1998; 9:839-847.
　·Wu L, Nichogainnopoulou A, Shortman K, Georgopoulos K. Cell autonomous defects in dendritic cell populations of ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 1997; 7:483-492.
　·Wu L, Li C-L, Shortman K.  Thymic dendritic cell precursors: relationship to the T-lymphocyte lineage and phenotype of the dendritic cell progeny.  J. Exp. Med. 1996; 184:903-911.
　·Ardavin C, Wu L, Li C-L, Shortman K. Thymic dendritic cells and T cells develop simultaneously within the thymus from a common precursor population. Nature 1993; 362: 761-763.
　·Wu L, Antica M, Johnson GR, Scollay R, Shortman K. Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med. 1991; 174: 1617-1627.
　·Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 1991; 349: 71-74.
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