纪家葵博士

教授，博导

1992-1997 美国爱荷华州立大学(生物化学系) 学士与硕士
1997-2003 美国康奈尔大学医学院/史隆凯特林癌症研究中心(分子、细胞生物与遗传学系) 博士
2004-2007 美国加州大学旧金山分校 博士后
2007-2010 美国斯坦福大学 副研究员
2010-至今 清华大学 教授

主要科研领域与方向：
（1）人类干细胞及生殖细胞的分化机制: 利用人类干细胞体外分化技术，结合分子生物学及细胞生物学，研究生殖细胞的分化机理，并发展体外分化成熟精子、卵子技术；
（2）人类遗传疾病的研究与治疗: 结合诱导多能干细胞(iPS)及定点基因重组技术, 研发治疗遗传疾病的途径。

1. Kehkooi Kee, Renee Reijo Pera, Paul Turek. Testicular Germline Stem Cell. Nature Review of Urology. 2010 Feb;7(2):94-100. [Epub 2010 Jan 19].
2. Kehkooi Kee, Vanessa Angeles, Marty Flores, Ha Nam Nguyen & Renee Reijo Pera. DAZL, DAZ, and BOULE modulate human primordial germ cell and haploid gamete formation. Nature. 2009 Nov 12; 462(7270):222-5. [Epub 2009 Oct 28].
3. International Stem Cell Initiative members. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nature Biotechnol. 2007 Jul; 25(7):803-16.
4. Kehkooi Kee, Joanna Gonsalves, and Renee Reijo Pera. Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells. Stem cell and Development. 2006 Dec; 15(6):831-37.
5. Kiersten A. Henderson, Kehkooi Kee, Shohreh Maleki, Paul Santini, and Scott Keeney. Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell. 2006 Jun 30; 125(7):1321-32.
6. Kehkooi Kee, Reine U. Protacio, Charanjit Arora and Scott Keeney. Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J. 2004 Apr 21;23(8):1815-24. [Epub :2004 Mar 25].
7. Charanjit Arora, Kehkooi Kee, Shohreh Maleki, and Scott Keeney. Antiviral protein Ski8 is a direct partner of Spo11 in meiotic double-strand break formation, independent of its cytoplasmic role in RNA metabolism. Molecular Cell, 2004 Feb 27;13(4):549-59.
8. Kehkooi Kee and Scott Keeney. Functional Interactions Between SPO11 and REC102 During Initiation of Meiotic Recombination in Saccharomyces cerevisiae. Genetics. 2002 Jan;160(1):111-22.
9. Kehkooi Kee, Luming Niu, and Eric Henderson. A Tetrahymena thermophila G4-DNA binding protein with dihydrolipoamide dehydrogenase activity. Biochemistry. 1998 Mar 24;37(12):4224-34.

联系方式:

电话：+86-10-62794200(办公室), 62785820(实验室)

Email: kkee@mail.tsinghua.edu.cn