俞立 博士

教授  博士生导师

国家“杰出青年基金”获得者、“长江学者奖励计划”特聘教授

简历

1994 四川大学生物系微生物专业 学士
2000 北京大学生命科学学院分子生物学专业 博士
2000~2008 美国国立卫生研究院 博士后
2008~至今 bte365正规网站 教授

主要科研领域与方向

综合细胞生物学，遗传学，生物化学，分子生物学等研究方法，以从酵母到小鼠等不同模式生物为模型研究1）俞立实验室发现的新细胞器迁移体（Migrasome）的机制与功能。2）自吞噬在细胞及分子水平上的调控机制。

代表论文

1. Yi C, Tong J, Lu P, Wang Y, Zhang J, Sun C, Yuan K, Xue R, Zou B, Li N, Xiao S, Dai C, Huang Y, Xu L, Li L, Chen S, Miao D, Deng H, Li H, Yu L*. Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration. Developmental Cell. 2017 Apr 10;41(1):59-71
2. Du W, Su QP, Chen Y, Zhu Y, Jiang D, Rong Y, Zhang S, Zhang Y, Ren H, Zhang C, Wang X, Gao N, Wang Y, Sun L, Sun Y*, Yu L*. Kinesin 1 Drives Autolysosome Tubulation. Developmental Cell. 2016 May 23;37(4):326-36
3. Na Mi*, Yang Chen, Shuai Wang, Mengran Chen, Mingkun Zhao, Guang Yang, Meisheng Ma, Qian Su, Sai Luo, Jingwen Shi, Jia Xu, Qiang Guo, Ning Gao, Yujie Sun, Zhucheng Chen* & Li Yu*. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology. 2015 Sep;17(9):1112-23
4. Chong Wang, Wanqing Du, Qian Peter Su, Mingli Zhu, Peiyuan Feng, Ying Li, Yichen Zhou, Na Mi, Yueyao Zhu, Dong Jiang, Senyan Zhang, Zerui Zhang, Yujie Sun* & Li Yu* Dynamic tubulation of mitochondria drives mitochondrial network formation. Cell Research. 2015 Oct;25(10):1108-20 (Cover story)
5. Ma L, Li Y, Peng J, Wu D, Zhao X, Cui Y, Chen L, Yan X, Du Y, Yu L*. Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration. Cell Research. 2015, Jan;25(1):24-38. (Cover Story)
6. Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, Hao Q, Li R, Yu L*. The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation. Journal of Cell Biol. 2014 Jul 21;206(2):173-82.
7. Yueguang Rong, Mei Liu, Liang Ma, Wanqing Du, Hanshuo Zhang, Yuan Tian, Zhen Cao, Ying Li, He Ren, Chuanmao Zhang, Lin Li, She Chen, Jianzhong Xi*&Li Yu* Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation. Nature Cell Biology, Sep;14(9):924-34
8. Cong Yi, Meisheng Ma, Leili Ran, Jingxiang Zheng, Jingjing Tong, Jing Zhu, Chengying Ma, YufenSun, ShaojinZhang, Wenzhi Feng, Liyuan Zhu, Yan Le, Xingqi Gong, Xianghua Yan, Bing Hong, Fen-Jun Jiang, Zhiping Xie, Di Miao,Haiteng Deng & Li Yu* Function and molecular mechanism of acetylation in autophagy regulation. 2012 Apr 27, 474-477, Science
9. Huang W, Choi W, Hu W, Mi N, Guo Q, Ma M, Liu M, Tian Y, Lu P, Wang FL, Deng H, Liu L, Gao N, Yu L*, Shi Y*. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res. 2012 Feb 7
10. Yueguang Rong , Christina K. McPhee, Shuangshen Deng , Lei Huang , Lilian Chen, Mei Liu, Kirsten Tracy, Eric H. Baehrecke, Li Yu* and Michael J. Lenardo, Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation. PNAS, 2011 Apr 25
11. Ye Tian, Zhipeng Li, Wanqiu Hu, Haiyan Ren, E Tian, Yu Zhao, Qun Lu, Xinxin Huang, Peiguo Yang, Xin Li, Xiaochen Wang, Attila L. Kovács, Li Yu*, and Hong Zhang*. C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell,  2010 Jun 11;141(6):1042-1055  
12. Li Yu, Christina K. McPhee, Lixin Zheng, Gonzalo A. Mardones, Yueguang Rong, Junya Peng, Na Mi, Ying Zhao, Zhihua Liu, Fengyi Wan, Dale W. Hailey, Viola Oorschot, Judith Klumperman, Eric H. Baehrecke, and Michael J. Lenardo*, Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature,  2010 Jun 6. [Epub ahead of print] ·
13. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004 Jun 4; 304(5676):1500-2
14. Yu L, Fengyi Wan, Sudeshna Dutta, Sarah Weish, Zhihua Liu, Eric Freundt, Erich. Baehrecke, and Michael Lenardo. Autophagic programmed cell death by selective catalase degradation. PNAS. March 17,2006.
15. Yu L, Mindy C Hebert, Ying Zhang. TGF-beta receptor-activated p 38 MAP kinase mediates Smad-independent TGF-beta response. EMBO. J 2002 Jul 15; 21(14): 3749-59
16. Yu L, Strandberg L, Lenardo MJ. The selectivity of autophagy and its role in cell death and survival. Autophagy. 2008 Jul 1; 4(5):567-73

荣誉、奖励及参加学术团体的情况

2012年“揭示营养匮乏引发细胞自噬的分子机制”荣获2012年度中国科学十大进展

2013年  荣获2013年度第六届谈家桢生命科学创新奖

2016年  创新人才推进计划中青年科技创新领军人才

联系方式

电话：+86-10-62792880(办公室)

E-mail: liyulab@mail.tsinghua.edu.cn