熊巍  博士

研究员，博士生导师

中组部“青年千人”入选者，基金委优秀青年科学基金

教育经历

1999      武汉大学生命科学学院  学士

2006     中科院神经科学研究所  博士

工作经历

2006-2007    北京大学分子医学研究所     研究助理

2007-2014   The Scripps Research Institute       Postdoc/Staff Scientist

2015-            bte365正规网站  研究员，博士生导师

主要研究领域与方向

1. 听觉毛细胞的机械敏感性；
2. 听觉通路对于声音的调制；
3. 耳聋发生的致病机理；
4. 耳聋的生物学治疗。

SELECTED PUBLICATIONS

1. Chen, J.#, Zhang, X.#, Li, J., Song, C., Jia, Y.*, and Xiong, W.* (2016). Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome. Neural Plast 2016, 5836143.
2. Beurg, M., Xiong, W., Zhao, B., Muller, U., and Fettiplace, R. (2015). Subunit determination of the conductance of hair-cell mechanotransducer channels. Proc Natl Acad Sci U S A 112, 1589-1594.
3. Xiong, W.*, T. Wagner, L. Yan, N. Grillet, and U. Muller.* "Using Injectoporation to Deliver Genes to Mechanosensory Hair Cells." Nat Protoc 9, no. 10 (2014): 2438-49.
4. Shang, S., C. Wang, B. Liu, Q. Wu, Q. Zhang, W. Liu, L. Zheng, H. Xu, X. Kang, X. Zhang, Y. Wang, H. Zheng, S. Wang, W. Xiong*, T. Liu*, and Z. Zhou*. "Extracellular Ca(2)(+) Per Se Inhibits Quantal Size of Catecholamine Release in Adrenal Slice Chromaffin Cells." Cell Calcium 56, no. 3 (2014): 202-7.
5. Zheng, L., Wang, C., Shang, S., Zhang, X., Wang, Y., Wu, Q., Hu, M., Chai, Z., Wu, X., Zheng, H., Zhang, C., Wang, L.*, Xiong, W. *, and Zhou, Z. * “Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells,” Am J Physiol Cell Physiol 305, no. 7 (2013): p. 751-60.
6. Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F.J., Zhao, B., Johnson, K. R., Kazmierczak, P. and Müller, U., “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells,” Cell 151, no. 6 (2012): p. 1283-95. (Reviewed by Faculty of 1000 [F1000Prime.com/717967202])
7. Xiong, W.#, Liu, T.#, Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C. X. and Zhou, Z., "An Inhibitory Effect of Extracellular Ca on Ca-Dependent Exocytosis," PLoS One 6, no. 10 (2011): e24573.
8. Grillet, N.#, Xiong, W.#, Reynolds, A.#, Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. and Müller, U., "Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells," Neuron 62, no. 3 (2009): 375-387. Featured in Neuron Previews in the same issue)
9. Schwander, M., Xiong, W., Tokita, J., Lelli, A., Elledge, H. M., Kazmierczak, P., Sczaniecka, A., Kolatkar, A., Wiltshire, T., Kuhn, P., Holt, J. R., Kachar, B., Tarantino, L. and Müller, U., "A Mouse Model for Nonsyndromic Deafness (Dfnb12) Links Hearing Loss to Defects in Tip Links of Mechanosensory Hair Cells," Proc Natl Acad Sci U S A 106, no. 13 (2009): 5252-5257. (Featured in Proc Natl Acad Sci U S A Commentary in the same issue)

 (#, Co-first Author; *, Co-correspondence Author)

联系方式

地址：医学科学楼B216，bte365正规网站，北京100084

电话： +86-10-62792464

Email: wei_xiong@tsinghua.edu.cn

实验室网站：http://www.neurocomlab.org/