欧光朔
研究员，博导
1994-2001 中国农业大学生物学院，获理学学士、硕士学位
2001-2006 美国加利福尼亚州大学戴维斯分校，获细胞和发育生物学博士学位
2007-2011 美国加利福尼亚州大学旧金山分校/霍华德休斯医学研究院 (HHMI)，博士后
2011-2013 中国科学院生物物理研究所，研究员，博士生导师
现任清华大学研究员、博士生导师
主要研究领域与方向
我们以线虫的Q神经前体细胞为对象，研究细胞骨架和信号转导蛋白如何调控神经系统的发育。Q神经前体细胞发育过程包括不对称分裂、长距离迁移、细胞凋亡及神经丝的形成，最终产生触觉神经元和中间神经元。我们建立了活体荧光显微成像方法，在细胞器和分子水平上实时记录Q细胞发育过程。我们发展了对线虫野生型基因组进行条件性基因突变方法，研究Q细胞发育分子机制。
近期代表论文
- Spectraplakin Induces Positive Feedback between Fusogens and the Actin Cytoskeleton to Promote Cell-Cell Fusion. Yang Y, Zhang Y, Li WJ, Jiang Y, Zhu Z, Hu H, Li W, Wu JW, Wang ZX, Dong MQ, Huang S, Ou G*. Developmental Cell. 2017 Apr 10;41(1):107-120.
- Feng G, Zhu Z, Li W, Chai Y, Dong M and Ou G*. Hippo Kinases Maintain Polarity during Directional Cell Migration in C. elegans. EMBO J. 2017 Feb 1;36(3):334-345.
- Zhu Z, Chai Y, Jiang Y, Li WJ, Hu H, Li W, Wu J, Wang Z, Huang S and Ou G*. Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Developmental Cell. 2016 Oct 24;39(2):224-238.
- Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S and Ou G*.(2015) Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Current Biology. 2015 May 4; 25(9):1135-45.
- Li WJ, Yi P and Ou G*. (2015) Somatic CRISPR/Cas9-induced Mutations Reveal Roles of Embryonically Essential Dynein Chains in Caenorhabditis elegans Cilia. J. Cell Biol. 2015 March 16; 208 (6)
- Shen Z, Zhang X, Chai Y, Zhu Z, Yi P, Feng G, Li W and Ou G.* (2014) Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development. Developmental Cell. 2014 Sept 08; 30(5):625-36.
- Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *, and Ou G.* (2013) Conditional Targeted Genome Editing Using Somatically Expressed TALENs in C. elegans. Nature Biotechnology. 2013 Oct;31(10):934-7.
- Feng G, Yi P, Yang Y, Chai Y, Tian D, Zhu Z, Liu J, Zhou F, Cheng Z, Wang X, Li W, and Ou G.* (2013) Developmental Stage-Dependent Transcriptional Regulatory Pathways Control Neuroblast Lineage Progression. Development. 2013 Aug 14.
- Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, Feng G, Li W, and Ou G.* (2013) Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11175-80.
- Chai Y, Tian D, Feng G, Cheng Z, Yang Y, Li W and Ou, G.* (2012) Apoptotic Regulators Promote Midbody Degradation in C. elegans. Journal of Cell Biology. 2012 Dec; 199(7):1047-55.
- Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677-80.
- Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature. 436(7050):583-7.
联系方式
电 话：+86-10-62794766
E-mail：guangshuoou@mail.tsinghua.edu.cn
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